Akari Yoneda, Shogo Takeda, Kenchi Miyasaka, Yoshiaki Manse, Toshio Morikawa, Hiroshi Shimoda. Epidermal and blood vessel barrier functions of glucosylceramides and digalactosyldiacylglycerols isolated from yellow strawberry guava. Processes, 12, 1421 (2024).
Seiji Tanaka, Naoko Masumoto, Takuya Makino, Yuji Matsushima, Toshio Morikawa, Michiho Ito. Novel compounds isolated from health food products containing beni-koji (red yeast rice) with adverse event reports. J. Nat. Med., 78, 845–848 (2024).
Toshio Morikawa, Naoki Inoue, Saya Yamamoto, Miyuki Shiotani, Yoshiaki Manse, Kiyofumi Ninomiya. Alkylphthalides with intracellular triglyceride metabolism‐promoting activity from the rhizomes of Cnidium officinale Makino. J. Nat. Med., 78, 709–721 (2024).
Kenchi Miyasaka, Ryuya Takada, Jianbo Wu, Shogo Takeda, Yoshiaki Manse, Toshio Morikawa, Hiroshi Shimoda. Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption. J. Nat. Med., 78, 693–701 (2024).
Takafumi Saeki, Saya Yamamoto, Junji Akaki, Takahiro Tanaka, Misaki Nakasone, Hidemasa Ikeda, Wei Wang, Makoto Inoue, Yoshiaki Manse, Kiyofumi Ninomiya, Toshio Morikawa. Ameliorative effect of bofutsushosan (Fangfengtongshengsan) extract on the progression of aging-induced obesity. J. Nat. Med., 78, 576–589 (2024).
Katsuki Takashima, Shinya Nakamura, Maiko Nagayama, Shinsuke Marumoto, Fumihiro Ishikawa, Weijia Xie, Isao Nakanishi, Osamu Muraoka, Toshio Morikawa, Genzoh Tanabe. Role of the thiosugar ring in the inhibitory activity of salacinol, a potent alpha-glucosidase inhibitor. RSC Adv., 14, 4471–4481 (2024).
Akifumi Nagatomo, Mamiko Kohno, Hirosato Kawakami, Yoshiaki Manse, Toshio Morikawa. Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver. J. Nat. Med., 78, 181–190 (2024).
Katsuki Takashima, Akane Asai, Mina Ashidate, Riko Suzuki, Shinsuke Marumoto, Fumihiro Ishikawa, Toshio Morikawa, Genzoh Tanabe. Total synthesis of calanthoside, a potential hair growth stimulant: a facile synthetic approach via one-pot S- and O-glucosidic bond formation. J. Nat. Prod., 86, 2672-2684 (2023).
Toshio Morikawa. Pharmaceutical food science: search for bio-functional molecules obtained from natural resources to prevent and ameliorate lifestyle disease. Chem. Pharm. Bull., 71, 756-765 (2023). Review (Cover page)
Hiroshi Shimoda, Shogo Takeda, Kenchi Miyasaka, Akari Yoneda, Yoshiaki Manse, Toshio Morikawa. Diverse effects of single molecules of rice-dirived functional lipids, glucosylceramides, ceramides, and beta-sitosterol glucoside, on epidermal and lung functions. Glycative Stress Res., 10, 94-109 (2023).
Hisashi Matsuda, Toshio Morikawa, Seikou Nakamura, Osamu Muraoka, Masayuki Yoshikawa. New biofunctional effects of oleanane-type triterpene saponins. J. Nat. Med., 77, 644-664 (2023). Review
Yusuke Sakamoto, Naoki Inoue, Yusuke Nakanishi, Kiyofumi Ninomiya, Masayuki Yoshikawa, Osamu Muraoka, Yoshiaki Manse, Toshio Morikawa. Hepatoprotective principles from the rhizomes of Picrorhiza kurroa. Biol. Pharm. Bull., 46, 848-855 (2023).
Hisashi Matsuda, Akifumi Nagatomo, Misaki Hatakeyama, Yoshiaki Manse, Masayuki Yoshikawa, Toshio Morikawa. Suppressive effects of Bombycis Feces (bombyx feces) and Bombyx Batryticatus (stiff silkworm) extracts on blood glucose level elevation in disaccharides-loaded rats. Tradit. Kampo Med., 10, 132-141 (2023).
Fenglin Luo, Yoshiaki Manse, Saowanee Chaipech, Yutana Pongpiriyadacha Osamu Muraoka and Toshio Morikawa. Structures of mammeasins P and Q, coumarin-related polysubstituted benzofurans from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders.: anti-proliferative activity of coumarin constituents against human prostate carcinoma cell line LNCaP. Pharmaceuticals, 16, 231 (2023).
Fenglin Luo, Yoshiaki Manse, Satoshi Ishikawa, Sakura Nishi, Anshin Chen, Tao Wang, Toshio Morikawa. Aromatase inhibitors isolated from a flowering tea, snow Chrysanthemum (the capitula of Coreopsis tinctoria Nutt.). J. Nat. Med. 387-396 (2023).
Takeda, Shogo, Akari Yoneda, Kenchi Miyasaka, Yoshiaki Manse, Toshio Morikawa, and Hiroshi Shimoda. Comparative study on epidermal moisturizing effects and hydration mechanisms of rice-derived glucosylceramides and ceramides. Int. J. Mol. Sci., 24, 83 (2023).
2022
Akifumi Nagatomo, Kiyofumi Ninomiya, Shinsuke Marumoto, Chie Sakai, Shuta Watanabe, Wakana Ishikawa, Yoshiaki Manse, Takashi Kikuchi, Takeshi Yamada, Reiko Tanaka, Osamu Muraoka, Toshio Morikawa. A Gedunin-Type Limonoid, 7-Deacetoxy-7-Oxogedunin, from Andiroba (Carapa guianensis Aublet) Reduced Intracellular Triglyceride Content and Enhanced Autophagy in HepG2 Cells. Int. J. Mol. Sci., 23, 13141 (2022).
Katsuki Takashima, Miyu Teramachi, Shinsuke Marumoto, Fumihiro Ishikawa, Yoshiaki Manse, Toshio Morikawa, Genzoh Tanabe. Structure-activity relationship study of 4,5-didehydroguadiscine, an aporphine alkaloid showing potent melanogenesis-inhibitory activity in B16 melanoma cells. Bioorg. Med. Chem. Lett., 78, 129034 (2022).
Fenglin Luo, Yoshiaki Manse, Saowanee Chaipech, Yutana Pongpiriyadacha, Osamu Muraoka, Toshio Morikawa. Phytochemicals with Chemopreventive Activity Obtained from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Isolation and Structure Dtermination of New Prenylcoumarins with Inhibitory Activity against Aromatase. Int. J. Mol. Sci., 23, 11233 (2022).
Kenchi Miyasaka, Yoshiaki Manse, Akari Yoneda, Shogo Takeda, Norihito Shimizu, Wakana Yamada, Toshio Morikawa, Hiroshi Shimoda. Anti-melanogenic effects of glucosylceramides and elasticamide derived from rice oil by-products in melanoma cells, melanocytes, and human skin. J. Food Biochem., 46, e14353 (2022).
Shogo takeda, Kenchi Miyasaka, Sarita Shrestha, Yoshiaki Manse, Toshio Morikawa, Hiroshi Shimoda. Lycoperoside H, a tomato seed saponin, improve epidermal dehydration by increasing ceramide in the stratum corneum and steroidal anti-inflammatory effect. Molecules, 26, 5860 (2021). News lease
Yongli Guo, Qingling Cui, Shumeng Ren, Deguo Hao, Toshio Morikawa, Dongmei Wang, Xiaoqiu Liu, Yingni Pan. The hepatoprotective efficacy and biological mechanisms of three phenylethanoid glycosides from cistanches herba and their metabolites based on intestinal bacteria and network pharmacology. J. Nat. Med.,75, 784-797 (2021).
Toshio Morikawa, Kiyofumi Ninomiya, Genzoh Tanabe, Hisashi Matsuda, Masayuki Yoshikawa, Osamu Muraoka. A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia. J. Nat. Med., 75, 449-466 (2021).
Wei Zhang, Kun Ren, Shumeng Ren, Shuang Lv, Yingni Pan, Dongmei Wang, Toshio Morikawa, Xiaoqiu Liu. UPLC-Q-Exactive-MS analysis for the hepatotoxicity components of Evodiae Fructus based on spectrum-toxicity relationship. J. Chromatogr. B., 1176,122772 (2021).
Toshio Morikawa, Yoshiaki Manse, Fenglin Luo, Haruko Fukui, Yamato Inoue, Tsuyoshi Kaieda, Kiyofumi Ninomiya, Osamu MMuraoka, Masayuki Yoshikawa. Indole Glycosides from Calanthe discolor with Proliferative Activity on Human Hair Follicle Dermal Papilla Cells. Chem. Pharm. Bull., 69, 464-471 (2021). Featured Article
Masakazu Kobayashi, Junji Akaki, Kiyofumi Ninomiya, Masayuki Yoshikawa, Osamu Muraoka, Toshio Morikawa, Masato Odawara. Dose-Dependent Suppression of Postprandial Hyperglycemia and Improvement of Blood Glucose Parameters by Salacia chinensis Extract: Two Randomized, Double-Blind, Placebo-Controlled Studies. J. Med. Food, 24 (1),10-17 (2021).
Yoshiaki Manse, Fenglin Luo, Kazuhiro Kato, Akane Okazaki, Eriko Okada-Nishida, Mitsuhiro Yanagita, Sho Nakamura, Toshio Morikawa. Ent-kaurane-type diterpenoids from Isodonis Herba activate human hair follicle dermal papilla cells proliferation via the Akt/GSK-3β/β-catenin transduction pathway. J. Nat. Med. in Online. News Release
Katsuki Takashima, Mika sakano, Eri Kinouchi, Shinya Nakamura, Shinsuke Marumoto, Fumihiro Ishikawa, Kiyofumi Ninomiya, Isao Nakanishi, Toshio Morikawa. Elongation of the side chain by linear alkyl groups increases the potency of salacinal, a potent α-glucosidase inhibitor from the Ayurvedic traditional medicine "Salacia", against human intestinal maltase. Bioorg. Med. Chem. Lett., 33, 127751 (2021).
Fenglin Luo, Hidemi Sugita, Kenichi Muraki, Shunsuke Saeki, Saowanee Chaipech, Yunata Pongpiriyadacha, Osamu Muraoka, Toshio Morikawa. Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines. Fitoterapia, 148, 104780 (2021).
2020
Tsuyoshi Takara, Kazuo Yamamoto, Naoko Szuki, Shinichiro Yamashita, Shinichiro Lio, Hayata Noguchi, Toshihiro Kakinuma, Saya Yamamoto, Toshio Morikawa, Shogo Takeda, Hiroshi Shimoda. Moriche Palm (Aguaje) Extract improves indefinite complaints in Japanese females: a randomized, placebo-controlled, double-blind trial. Functional Foods in Health and Disease 2020, 10 (9), 379-396 (2020).
Toshio Morikawa, Satoru Tamura, Tao Wang, Discovery and Total Synthesis of Bio-functional Natural Products From Traditional Medicinal Plants. Front. Chem., 8, 650 (2020). Editorial.
Wei Zhang, Jingyan Guo, Dongmei Wang, Shumeng Ren, Huiming Hua, Toshio Morikawa, Yingni Pan, Xiaoqiu Liu. Effect of CYP3A inducer/inhibitor on pharmacokinetics of five alkaloids in Evodiae Fructus. Chem.-Biol. Interact.,327, 109146 (2020).
ToshioMorikawa, Naoki Inoue, Yusuke Nakanishi, Yoshiaki Manse, Hideyuki Matsuura, Kenji Okino, Shinya Hamasaki, Masayuki Yoshikawa, Osamura Muraoka. Collagen synthesis-promoting and collagenase inhibitory activities of constituents isolated from the rhizomes of Picrorhiza kurroa Royle ex Benth. Fitoterapia, 143, 104584 (2020).
