Toshio Morikawa, Itadaki Yamaguchi, Hisashi Matsuda, Masayuki Yoshikawa: A new amide, piperchabamide F, and two new phenylpropanoid glycosides, piperchabaosides A and B, from the fruit of Piper chaba.Chem. Pharm. Bull., 57, 1292-1295 (2009).
Hisashi Matsuda, Kiyofumi Ninomiya, Toshio Morikawa, Daisuke Yasuda, Itadaki Yamaguchi, Msayuki Yoshikawa: Hepatoprotective amide constituents from the fruit of Piper chaba: structural requirements, mode of action, and new amide.Bioorg.Med. Chem., 17, 7313-7323 (2009).
Masayuki Yoshikawa, Toshio Morikawa, Hideo Oominami, Hisashi Matsuda: Absolute stereostructures of olibanumols A, B, C, H, I, and J from olibanum, gum-resin of Boswellia carterii, and inhibitors of nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages.Chem. Pharm. Bull., 57, 957-964 (2009).
Toshio Morikawa, Yuanyuan Xie, Yasunobu Asao, Masaki Okamoto, Chihiro Yamashita, Osamu Muraoka, Hisashi Matsuda, Yutana Pongpiriyadacha, Dan Yuan, Masayuki Yoshikawa: Oleanane-type triterpenenoligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak.Phytochemistry, 70, 1166-1172 (2009).
Toshio Morikawa, Wang Li-Bo, Kiyofumi Ninomiya, Seikou Nakamura, Hisashi Matsuda, Osamu Muraoka, Wu Li-Jun, Masayuki Yoshikawa: Medicinal flowers. XXX. eight new glycosides, everlastosides F-M, from the flowers of Helichrysum arenarium.Chem. Pharm. Bull., 57, 853-859 (2009).
Osamu Muraoka, Toshio Morikawa, Yi Zhang, Kiyofumi Ninomiya, Seikou Nakamura, Hisashi Matsuda, Masayuki Yoshikawa: Novel megastigmanes with lipid accumulation inhibitory and lipid metabolism-promoting activities in HepG2 cells from Sedum sarmentosum.Tetrahedron, 65, 4142-4148 (2009).
Li-Bo Wang, Toshio Morikawa, Seikou Nakamura, Kiyofumi Ninomiya, Hisashi Matsuda, Osamu Muraoka, Li-Jun Wu, Masayuki Yoshikawa: Medicinal flowers. XXVIII. structures of five new glycosides, everlastsides A, B, C, D, and E, from the flowers of Helichrysum arenarium.Heterocycles, 78, 1235-1242 (2009).
Toshio Morikawa, Haihui Xie, Tao Wang, Hisashi Matsuda, Masayuki Yoshikawa: Acylated flavonol bisdesmosides, sinocrassosides A3-A7 and B3, with aminopeptidase N inhibitory activity fromSinocrassula indica.Chem. Biodiv., 6, 411-420 (2009).
Toshio Morikawa, Li-Bo Wang, Seikou Nakamura, Kiyofumi Ninomiya, Eri Yokoyama, Hisashi Matsuda, Osamu Muraoka, Li-Jin Wu, Masayuki Yoshikawa: Medicinal flowers. XXVII. new flavanone and chalcone glycosides, arenariumosides I, II, III, and IV, and tumor necrosis factor-alfa inhibitors from Everlasting, flowers of Helichrysum arenarium.Chem. Pharm. Bull., 57, 316-367 (2009).
Yasunobu Asao., Toshio Morikawa, Yuanyuan Xie, Masaki Okamoto, Makoto Hamao, Hisashi Matsuda, Osamu Muraoka, Dan Yuan, Masayuki Yoshikawa: Structures of acetylated oleanane-type triterpene saponins, rarasaponins IV, V, and VI, and anti-hyperlipidemic constituents from the pericarps of Sapindus rarak.Chem. Pharm.Bull., 57, 198-203 (2009).
2008
Seikou Nakamura, Yoshie Okazaki, Kiyofumi Ninomiya, Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa: Medicinal flowers. XXIV. chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium.Chem. Pharm. Bull., 56, 1704-1709 (2008).
Yuanyuan Xie, Toshio Morikawa, Kiyofumi Ninomiya, Katsuya Imura, Osamu Muraoka, Dan Yuan, Masayuki Yoshikawa: Medicinal Flowers. XXIII. new taraxastane-type triterpene, punicanolic acid, with tumor necrosis factor-alfa inhibitory activity from the flowers of Punica granutum.Chem. Pharm. Bull., 56, 1628-1631 (2008).
Toshio Morikawa, Haihui Xie, Tao Wang, Hisashi Matsuda, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XXXII. aminopeptidase N and aldose reductase inhibitors from Sinocrassula indica: structures of sinocrassosides B4, B5, C1, and D1-D3.Chem. Pharm. Bull., 56, 1438-1444 (2008).
Koyofumi Ninomiya, Toshio Morikawa, Haihui Xie, Hisashi Matsuda, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XXXI. hepatoprotective principles from Sinocrassula indica: structures of sinocrassosides A8, A9, A10, A11, and A12.Heterocycles, 75, 1983-1995 (2008).
Toshiko Morikawa, Kanako Funakoshi, Kiyofumi Ninomiya, Daisuke Yasuda, Katsutoshi Miyagawa, Hisashi Matsuda, Masayuki Yoshikawa: Medicinal foodstuffs. XXXIV. structures of new prenylchalcones and prenylflavanones with TNF-alfa and aminopeptidase N inhibitory activities from Boesenbergia rotunda.Chem. Pharm.Bull., 56, 956-962 (2008).
Masayuki Yoshikawa, Toshio Morikawa, Kanako Funakoshi, Momotaro Ochi, Yutana Pongpiriyadacha, Hisashi Matsuda: Medicinal foodstuffs. XXXIII. gastroprotective principles from Boesenbergia rotunda (Zingiberaseae)-absolute stereostructures of Diels-Alder type addition prenylchalcones-.Heterocycles, 75, 1639-1650 (2008).
Toshio Morikawa, Xuezheng Li, Eriko Nishida, Yuki Ito, Hisashi Matsuda, Seikou Nakamura, Osamu Muraoka, Masayuki Yoshikawa: Perennisosides I-VII, acylated triterpene saponins with antihyperlipidemic activities from the flowers of Bellis perennis.J. Nat. Prod., 71, 828-835 (2008).
Masayuki Yoshikawa, Xuezheng Li, Eriko Nishida, Seikou Nakamura, Hisashi Matsuda, Osamu Muraoka, Toshio Morikawa: Medicinal Flowers. XXI. Structures of Perennisaponins A, B, C, D, E, and F, acylated oleanane-type triterpene oligoglycosides, from the flowers of Bellis perennis.Chem. Pharm. Bull., 56, 559-568 (2008).
Hisashi Matsuda, Kiyofumi Ninomiya, Toshio Morikawa, Daisuke Yasuda, Itadaki Yamaguchi, Masayuki Yoshikawa: Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-alfa-induced cell death in mouse hepatocytes.Bioorg. Med. Chem. Lett., 18, 2038-2042 (2008).
2007
Toshio Morikawa, Hisashi Matsuda, Li N., Li X., Masayuki Yoshikawa: Bioactive saponins and glycosides. XXIX. Acylated oleanane-type triterpene saponins: Theasaponins A6, A7, and B5, from the seeds of Camellia sinensis.Helv. Chim. Acta, 90, 2342-2348 (2007).
Seukou Nakamura, Xuezheng Li, Hisashi Matsuda, Kiyofumi Ninomiya, Toshio Morikawa, Kikuji Yamaguti, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XXVI. Chemical structures and hepatoprotective effects of constituents from roots of Rhodiola sachalinensis.Chem. Pharm. Bull.., 55, 1505-1511 (2007).Cover Page
Masayuki Yoshikawa, Tao Wang,Toshio Morikawa, Haihui Xie, Hisashi Matsuda: Bioactive constituents from Chinese natural medicines. XXIV. Hypoglycemic effects of Sinocrassula indica in sucrose-loaded rats and genetically diabetic KK-Ay mice and structures of new acylated flavonol glycosides, sinocrassosides A1, A2, B1, and B2.Chem. Pharm. Bull., 55, 1308-1315 (2007).
Kiyofumi Ninomiya, Toshio Morikawa, Yi Zhang, Seukou Nakamura, Hisashi Matsuda, Osamu Muraoka, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XXIII. Absolute structures of new megastigmane glycosides, sedumosides A4, A5, A6, H, and I, and hepatoprotective megastigmanes from Sedum sarmentosum.Chem. Pharm. Bull., 55, 1185-1191 (2007).
Yi Zhang, Toshio Morikawa, Seukou Nakamura, Kiyofumi Ninomiya, Hisashi Matsuda, Osamu Muraoka, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XXV. New flavonol bisdesmosides, sarmenosides I, II, III, and IV, with hepatoprotective activity from Sedum sarmentosum.Heterocycles., 71, 1565-1576 (2007).
Kiyofumi Ninomiya, Hisashi Matsuda, Mizuho Kubo, Toshio Morikawa, Norihisa Nishida, Masayuki Yoshikawa: Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside.Bioorg. Med. Chem.Lett., 17, 3059-3064 (2007).
Ning Li, Toshio Morikawa, Hisashi Matsuda, Kiyofumi Ninomiya, Xian Li, Masayuki Yoshikawa: New flavanone oligoglycosides, theaflavanosides I, II, III, and IV, with hepatoprotective activity from the seeds of tea plant (Camellia sinensis).Heterocycles, 71, 1193-1201 (2007).
Masayuki Yoshikawa, Toshio Morikawa, Yi Zhang, Seikou Nakamura, Osamu Muraoka, Hisashi Matsuda: Megastigmanes and their glucosides from the whole plant of Sedum sarmentosum.J. Nat. Prod., 70, 575-583 (2007).
Masayuki Yoshikawa, Toshio Morikawa, Yasunobu Asao, Emi Fujiwara, SEikou Nakamura, Hisashi Matsuda: MEdicinal flowers. XV. The structures of noroleanane- and oleanane-type triterpene oligoglycosides with gastroprotective and platelet aggregation activities from flower buds of Camellia japonica.Chem. Pharm. Bull., 55, 606-612 (2007).
Toshio Morikawa: Search for bioactive constituents from several medicinal foods: hepatoprotective, antidiabetic, and antiallergic activities.J. Nat. Med., 61, 112-126 (2007).Review
Toshio Morikawa, Yi Zhang, Seikou Nakamura, Hisashi Matsuda, Osamu Muraoka, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XXII. Absolute structures of new megastigmane glycosides, sedumosides E1, E2, E3, F1, F2, and G, from Sedum sarmentosum (Crassulaceae).Chem. Pharm. Bull., 55, 435-441 (2007).
Masayuki Yoshikawa, Toshio Morikawa, Hisanori Kobayashi, Akihiko Nakamura, Koudai Matsuhira, Seikou Nakamura, Hisashi Matsuda: Bioactive saponins and glycosides. XXVII. Structures of new cucurbitane-type triterpene glycosides and antiallergic constituents from Citrullus colocynthis.Chem. Pharm. Bull., 55, 428-434 (2007).
Masayuki Yoshikawa, Seikou Nakamura, Kenichi Ozaki, Akira Kumahara, Toshio Morikawa, Hisashi Matsuda: Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum. J. Nat. Prod., 70, 210-214 (2007).
Masayuki Yoshikawa, Fengming Xu, Toshio Morikawa, Yutana Pongpiriyadacha, Seikou Nakamura, Yasunobu Asao, Akira Kumahara, Hisashi Matsuda: Medicinal foodstuffs. XII. New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer.Chem. Pharm. Bull., 55, 308-316 (2007).
Toshio Morikawa, Seikou Nakamura, Yasuyo Kato, Osamu Muraoka, Hisashi Matsuda, Masayuki Yoshikawa: Bioactive saponins and glycosides. XXVIII. New triterpene saponins, foliatheasaponins I, II, III, IV, and V, from Tencha (the leaves of Camellia sinensis).Chem. Pharm. Bull., 55, 293-298 (2007).
Hisashi Matsuda, Sachiko Sugimoto, Toshio Morikawa, Koudai Matsuhira, Eri Mizuguchi, Seikou Nakamura, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia.Chem. Pharm. Bull., 55, 106-110 (2007).
Masayuki Yoshikawa, Toshio Morikawa, Seikou Nakamura, Ning Li, Xian Li, Hisashi Matsuda: Bioactive saponins and glycosides. XXV. Acylated oleanane-type triterpene saponins from the seeds of tea plant (Camellia sinensis).Chem. Pharm. Bull., 55, 57-63 (2007).
2006
Masayuki Yoshikawa, Toshio Morikawa, Junji Tanaka, Hiroshi Shimoda: Medicinal food stuffs. XXXII. Novel sesquiterpene glycoside sulfate, fukinoside A, with antiallergic activity from Japanese butterbur (Petasites japonicus).Heterocycles, 68, 2335-2342 (2006).
Toshio Morikawa, Fengming Xu, Hisashi Matsuda, Masayuki Yoshikawa: Structures of new flavonoids, erycibenins D, E, and F, and NO production inhibitors from Erycibe expansa originating in Thailand.Chem. Pharm. Bull., 54, 1530-1534 (2006).
Masayuki Yoshikawa, Hisashi Matsuda, Toshio Morikawa, Haihui Xie, Seikou Nakamura, Osamu Muraoka: Phenylethanoid oligoglycosides and acylated oligosugars with vasorelaxant activity from Cistanche tubulosa.Bioog. Med. Chem., 14, 7468-7475 (2006). Most Cited Paper 2006-2009 Award
Toshio Morikawa, Hisashi Matsuda, Ning Li, Seikou Nakamura, Xian Li, Masayuki Yoshikawa: Bioactive saponins and glycosides. XXVI. New triterpene saponins, theasaponins E10, E11, E12, E13, and G2, from the seeds of tea plant (Camellia sinensis).Heterocycles, 68, 1139-1148 (2006).
Toshio Morikawa, Haihui Xie, Hisashi Matsuda, Masayuki Yoshikawa: Glucosyloxybenzyl 2-isobutylmalates from the tubers of Gymnadenia conopsea.J.Nat. Prod., 69, 881-886 (2006).
Toshio Morikawa, Osama Bashir Abdel-Halim, Hisashi Matsuda, Shin Ando, Osamu Muraoka, Masayuki Yoshikawa: Pseudoguaiane-type sesquiterpenes and inhibitors on nitric oxide production from Dichrocephala integrifolia.Tetrahedron, 62, 6435-6442 (2006).
Haihui Xie, Toshio Morikawa, Hisashi Matsuda, Seikou Nakamura, Osamu Muraoka, Masayuki Yoshikawa: Monoterpene constituents from Cistanche tubulosa -chemical structures of kankanosides A-E and kankanol.Chem. Pharm. Bull., 54, 669-675 (2006).Cover Page
Toshio Morikawa, Haihui Xie, Hisashi Matsuda, Tao Wang, Masayuki Yoshikawa: Bioactive constituents from Chinese natural medicines. XVII. Constituents with radical scavenging effect and new glucosyloxybenzyl 2-isobutylmalates from Gymnadenia conopsea.Chem. Pharm. Bull., 54, 506-513 (2006).
Hiroshi Shimoda, Junji Tanaka, Emi Yamada, Toshio Morikawa, Naoki Kasajima, Masayuki Yoshikawa: Anti type I Allergic property nof japanese butterbur extract and its mast cell degranulation inhibitory ingredients.J. Agric. Food Chem., 54, 2915-2920 (2006).
Toshio Morikawa, Ning Li, Akifumi Nagatomo, Hisashi Matsuda, Xian Li, Masayuki Yoshikawa: Triterpene saponins with gastroprotective effects from tea seed (the seeds of Camellia sinensis).J. Nat. Prod., 69, 185-190 (2006).
Masayuki Yoshikawa, Norihisa Nishida, Kiyofumi Ninomiya, Teruki Ohgushi, Mizuho Kubo, Toshio Morikawa, Hisashi Matsuda: Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on D-galactosamine/lipopolysaccharide-induced liver injury in mice and on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages.Bioorg.Med. Chem., 14, 456-463 (2006).
Hisashi Matsuda, Shin Ando, Tomoko Kato, Toshio Morikawa, Masayuki Yoshikawa: Inhibitors from the rhizomes of Alpinia officinarum on production of nitric oxide in lipopolysaccharide-activated macrophages and the structural requirements of diarulheptanoids for the activity.Bioorg. Med. Chem., 14, 138-142 (2006).
Masayuki Yoshikawa, Toshio Morikawa, Ning Li, Akifumi Nagatomo, Xian Li, Hisashi Matsuda: Bioactive saponins and glycosides. XXIII. Triterpene saponins with gastroprotective effect from the seeds of Camellia sinensis-theasaponins E3, E4, E5, E6, and E7-.Chem. Pharm. Bull., 53, 1559-1564 (2005).
Hisashi Matsuda, Shin Ando, Toshio Morikawa, Shinya Kataoka, Masayuki Yoshikawa: Structure-activity relationships of 1'S-1'-acetoxychavicol acetate for inhibitory effect on NO production in lipopolysaccharide-activated mouse peritoneal macrophages.Bioorg. Med. Chem. Lett., 15, 1949-1953 (2005).
Shin Ando, Hisashi Matsuda, Toshio Morikawa, Masayuki Yoshikawa: 1'S-1'-Acetoxychavicol acetate as a new type inhibitor of interferon-b production in lipopolysaccharide-activated mouse peritoneal macrophages.Bioorg. Med. Chem., 13, 3289-3294 (2005).
Haihui Xie, Tao Wang, Hisashi Matsuda, Toshio Morikawa, Masayuki Yoshikawa, Tadato Tani: Bioactive constituents from Chinese natural medicines. XV. Inhibitory effect on aldose reductase and structures of saussureosides A and B from Saussurea medusa.Chem. Pharm. Bull., 53, 1416-1422 (2005).
Masayuki Yoshikawa, Toshio Morikawa, Kaori Yamamoto, Yasuyo Kato, Akifumi Nagatomo, Hisashi Matsuda: Floratheasaponins A-C, acylated oleanane-type triterpene oligoglycosides with anti-hyperlipidemic activities from flowers of the tea plant (Camellia sinensis).J. Nat. Prod., 68, 1360-1365 (2005).
Toshio Morikawa, Shin Ando, Hisashi Matsuda, Shinya Kataoka, Osamu Muraoka, Masayuki Yoshikawa: Inhibitors of nitric oxide production from the rhizomes of Alpinia galanga: Structures of new 8-9' linked neolignans and sesquineolignan.Chem.Pharm. Bull., 53, 625-630 (2005).
Hisashi Matsuda, Toshio Morikawa, Teruki Ohgushi, Tomoko Ishiwada, Norihisa Nishida, Masayuki Yoshikawa: Inhibitors of nitric oxide production from the flowers of Angelica furcijuga: Structures of hyuganosides IV and V.Chem. Pharm. Bull., 53, 387-392 (2005).
2004
Hisashi Matsuda, Toshio Morikawa, Fengming Xu, Kiyofumi Ninomiya, Masayuki Yoshikawa: New Isoflavones and Pterocarpane with Hepatoprotective Activity from the Stems of Erycibe expansa,Planta Med,, 70, 1201-1209 (2004).
Hisashi Matsuda, Supinya Tewtrakul, Toshio Morikawa, Akihiko Nakamura, Masayuki Yoshikawa: Anti-Allergic Principles from Thai Zedoary: Structural Requirements of Curcuminoids for Inhibition of Degranulation and Effect on the Release of TNF-a and IL-4 in RBL-2H3 Cells.Bioorg. Med. Chem., 12, 5891-5898 (2004).
Toshio Morikawa, Hisashi Matsuda, Norihisa Nishida, Teruki Ohgushi, Masayuki Yoshikawa: Structures of New Aromatics Glycosides from a Japanese Folk Medicine, the Roots of Angelica furcijuga.Chem. Pharm. Bull., 52, 1387-1390 (2004).
Hisashi Matsuda, Toshio Morikawa, Haihui Xie, Masayuki Yoshikawa: Antiallergic Phenanthrenes and Stilbenes from the Tubers of Gymnadenia conopsea.Planta Med., 70, 847-855 (2004).
Hisashi Matsuda, Toshio Morikawa, Shin Ando, Hideo Oominami, Toshiyuki Murakami, Ikuko Kimura, Masayuki Yoshikawa: Absolute Stereostructures of Polypodane-Type Triterpenes, Myrrhanol A and Myrrhanone A, from Guggul-Gum Resin (the Resin of Balsamodendron mukul).Chem. Pharm. Bull., 52, 1200?1203 (2004).
Toshio Morikawa, Bohang Sun, Hisashi Matsuda, Li Jun Wu, Shoichi Harima, Masayuki Yoshikawa: Bioactive Constituents from Chinese Natural Medicines. XIV. New Glycosides of β-carboline-Type Alkaloids, Neolignan, and Phynylpropanoid rom Stellaria dichotoma L. var. lnaceolata and Their Antiallergic Activities.Chem. Pharm.Bull., 52, 1194-1199 (2004).
Bohang Sun, Toshio Morikawa, Hisashi Matsuda, Supinya Tewtrakul, Li Jun Wu, Shoichi Harima, Masayuki Yoshikawa: Structures of New β-Carboline-Type Alkaloids with Antiallergic Effects from Stellaria dichotoma.J. Nat. Prod., 67, 1464-1469 (2004).
Hisashi Matsuda, Supinya Tewtrakul, Toshio Morikawa, Masayuki Yoshikawa: Anti-Allergic Activity of Stilbenes from Korean Rhubarb (Rheum undulatum L.): Structure Requirements for Inhibition of Antigen-Induced Degranulation and Their Effects on the Release of TNF-α and IL-4 in RBL-2H3 Cells.Bioorg. Med. Chem., 12, 4871-4876 (2004).
Osama Bashir Abdel-Halim, Toshio Morikawa, Shin Ando, Hisashi Matsuda, Masayuki Yoshikawa: New Crinine-Type Alkaloids with Inhibitory Effect on Induction of Inducible Nitric Oxide Synthase from Crinum yemense.J. Nat. Prod., 67, 1119-1124 (2004).
Hisashi Matsuda, Toshio Morikawa, Shin Ando, Hideo Oominami, Toshiyuki Murakami, Ikuko Kimura, Masayuki Yoshikawa: Absolute Stereostructures of Polypodane- and Octanordammarane-Type Triterpenes with Nitric Oxide Production Inhibitory Activity from Guggul-Gum Resins.Bioorg. Med. Chem., 12, 3037-3046 (2004).
Fengming Xu, Toshio Morikawa, Hisashi Matsuda, Kiyofumi Ninomiya, Masayuki Yoshikawa: Structures of New Sesquiterpenes and Hepatoprotective Constituents from the Egyptian Herbal Medicne Cyperus longus.J. Nat. Prod., 67, 569-576 (2004).
Kiyofumi Ninomiya, Hisashi Matsuda, Hiroshi Shimoda, Norihisa Nishida, Naoki Kasajima, Tomoe Yoshino, Toshio Morikawa, Masayuki Yoshikawa: Carnosic Acid, A New Class of Lipid Absorption Inhibitor from Sage.Bioorg. Med. Chem. Lett., 14, 1943-1946 (2004).
Toshio Morikawa, Fengming Xu, Kiyofumi Ninomiya, Hisashi Matsuda, Masayuki Yoshikawa: Nigellamines A3, A4, A5, and C, New Dolabellane-Type Diterpene Alkaloids, with Lipid Metabolism-Promoting Activities from the Egyptian Medicinal Food Black Cumin.Chem. Pharm. Bull., 52, 494-497 (2004).
Toshio Morikawa, Fengming Xu, Yousuke Kashima, Hisashi Matsuda, Kiyofumi Ninomiya, Masayuki Yoshikawa: Novel Dolabellane-Type Diterpene Alkaloids with Lipid Metabolism Promoting Activities from the Seeds of Nigella sativa.Org. Lett., 6, 869-872 (2004).
Toshio Morikawa, Hisashi Matsuda, Itadaki Yamaguchi, Yutana Pongpiriyadacha, Masayuki Yoshikawa: New Amides and Gastroprotective Constituents from the Fruit of Piper chaba.Planta Med., 70, 152-159 (2004).
2003
Hisashi Matsuda, Toshio Morikawa, Mamiko Oda, Yasunobu Asao, Masayuki Yoshikawa: Potent Anti-Metastatic Activity of Dimeric Sesquiterpene Thioalkaloids from the Rhizome of Nuphar pumilum.Bioorg. Med. Chem. Lett., 13, 4445-4449 (2003).
Hisashi Matsuda, Toshio Morikawa, Hiromi Managi, Masayuki Yoshikawa: Antiallergic Principles from Alpinia galanga: Structural Requirements of Phenylpropanoids for Inhibition of Degranulation and Release of TNF-alfa and IL-4 in RBL-2H3 Cells.Bioorg. Med. Chem. Lett., 13, 3197-3202 (2003).
Toshio Morikawa, Akinobu Kishi, Yutana Pongpiriyadacha, Hisashi Matsuda, Masayuki Yoshikawa: Structures of New Friedelane-Type Triterpenes and Eudesmane-Type Sesquiterpene and Aldose Reductase Inhibitors from Salacia chinensis.J. Nat. Prod., 66, 1191-1196 (2003).
Akinobu Kishi, Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa: Structures of New Friedelane- and Norfriedelane-Type Triterpenes and Polyacylated Eudesmane-Type Sesquiterpene from Salacia chinensis LINN. (S. prinoides DC., Hippocrateaceae) and Radical Scavenging Activities of Principal Constituents.Chem.Pharm. Bull., 51, 1051-1055 (2003).
Masayuki Yoshikawa, Toshio Morikawa, Yousuke Kashima, Kiyofumi Ninomiya, Hisashi Matsuda: Structures of New Dammarane-Type Triterpene Saponins from the Flower Buds of Panax notoginseng and Hepatoprotective Effects of Principal Ginseng Saponins.J. Nat. Prod., 66, 922-927 (2003).
Masayuki Yoshikawa, Toshio Morikawa, Fengming Xu, Shin Ando, Hisashi Matsuda: (7R,8S) and (7S,8R) 8?5' Linked Neolignans from Egyptian Herbal Medicine Anastatica hierochuntica and Inhibitory Activities of Lignans on Nitric Oxide Production.Heterocycles, 60, 1787-1792 (2003).
Hisashi Matsuda, Yutana Pongpiriyadacha, Toshio Morikawa, Momotaro Ochi, Masayuki Yoshikawa: Gastroprotective Effects of Phenylpropanoids from the Rhizomes of Alpinia galanga in Rats: Structural Requirements and Mode of Action.Eur. J. Pharmacol., 471, 59-67 (2003).
Jing Tao, Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa: Bioactive Constituents from Chinese Natural Medicines. XI. Inhibitors on NO Production and Degranulation in RBL-2H3 from Rubia yunnanensis: Structures of Rubianosides II, III, and IV, Rubianol-g, and Rubianthraquinone.Chem. Pharm. Bull., 51, 654-662 (2003).
Toshio Morikawa, Jing Tao, Shin Ando, Hisashi Matsuda, Masayuki Yoshikawa: Absolute Stereostructures of New Arborinane-Type Triterpenoids and Inhibitors of Nitric Oxide Production from Rubia yunnanensis.J. Nat. Prod., 66, 638-645 (2003).
Yutana Pongpiriyadacha, Hisashi Matsuda, Toshio Morikawa, Yasunobu Asao, Masayuki Yoshikawa: Protective Effects of Polygodial on Gastric Mucosal Lesions Induced by Necrotizing Agents in Rats and the Possible Mechanisms of Action.Biol.Pharm. Bull., 26, 651-657 (2003).
Hisashi Matsuda, Toshio Morikawa, Shin Ando, Iwao Toguchida, Masayuki Yoshikawa: Structural Requirements of Flavonoids for Nitric Oxide Production Inhibitory Activity and Mechanism of Action.Bioorg. Med. Chem., 11, 1995-2000 (2003).Most Cited Paper 2003-2006 Award
Hisashi Matsuda, Yutana Pongpiriyadacha, Toshio Morikawa, Akinobu Kishi, Shinya Kataoka, Masayuki Yoshikawa: Protective Effects of Steroid Saponins from Paris polyphylla var. yunnanensis on Ethanol- or Indomethacin-Induced Gastric Mucosal Lesions in Rats: Structural Requirement for Activity and Mode of Action.Bioorg. Med.Chem. Lett., 13, 1101-1106 (2003).
Masayuki Yoshikawa, Fengming Xu, Toshio Morikawa, Kiyofumi Ninomiya, Hisashi Matsuda: Anastatins A and B, New Skeletal Flavonoids with Hepatoprotective Activities from the Desert Plant Anastatica hierochuntica.Bioorg. Med. Chem. Lett., 13, 1045-1049 (2003).
Hisashi Matsuda, Toshio Morikawa, Tomoko Ishiwada, Hiromi Managi, Masatomo Kagawa, Yoshihiko Higashi, Masayuki Yoshikawa: Medicinal Flowers. VIII. Radical Scavenging Constituents from the Flowers of Prunus mume: Structure of Prunose III.Chem. Pharm. Bull., 51, 440-443 (2003).
Hisashi Matsuda, Iwao Toguchida, Kiyofumi Ninomiya, Tadashi Kageura, Toshio Morikawa, Masayuki Yoshikawa: Effects of Sesquiterpenes and Amino Acid?Sesquiterpene Conjugates from the Roots of Saussurea lappa on Inducible Nitric Oxide Synthase and Heat Shock Protein in Lipopolysaccharide-Activated Macrophages.Bioorg. Med. Chem., 11, 709-715 (2003). Most Cited Paper 2003-2006 Award
Hiroshi Shimoda, Kiyofumi Ninomiya, Norihisa Nishida, Tomoe Yoshino, Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa: Anti-hyperlipidemic Sesquiterpenes and New Sesquiterpene Glycosides from the Leaves of Artichoke (Cynara scolymus L.): Structure Requirement and Mode of Action. Bioorg. Med. Chem. Lett., 13, 223-228 (2003).
Toshio Morikawa, Jing Tao, Kazuho Ueda, Hisashi Matsuda, Masayuki Yoshikawa: Medicinal Foodstuffs. XXXI. Structures of New Aromatic Constituents and Inhibitors of Degranulation in RBL-2H3 Cells from a Japanese Folk Medicine, the Stem Bark of Acer nikoense.Chem. Pharm. Bull., 51, 62-67 (2003).
Toshio Morikawa, Jing Tao, Iwao Toguchida, Hisashi Matsuda, Masayuki Yoshikawa: Structures of New Cyclic Diarylheptanoids and Inhibitors of Nitric Oxide Production from Japanese Folk Medicine Acer nikoense.J. Nat. Prod., 66, 86-91 (2003).
2002
Masayuki Yoshikawa, Toshio Morikawa, Kyoko Nakano, Yutana Pongpiriyadacha, Toshiyuki Murakami, Hisashi Matsuda: Characterization of New Sweet Triterpene Saponins from Albizia myriophylla.J. Nat. Prod., 65, 1638-1642 (2002).
Jing Tao, Toshio Morikawa, Iwao Toguchida, Shin Ando, Hisashi Matsuda, Masayuki Yoshikawa: Inhibitors of Nitric Oxide Production from the Bark of Myrica rubra: Structures of New Biphenyl Type Diarylheptanoid Glycosides and Taraxerane Type Triterpene.Bioorg. Med. Chem., 10, 4005-4012 (2002).
Toshio Morikawa, Fengming Xu, Hisashi Matsuda, Masayuki Yoshikawa: Structures and Radical Scavenging Activities of Novel Norstilbene Dimer, Longusone A, and New Stilbene Dimers, Longusols A, B, and C, from Egyptian Herbal Medicines Cyperus longus.Heterocycles, 57, 1983-1988 (2002).
Toshio Morikawa, Hisashi Matsuda, Iwao Toguchida, Kazuho Ueda, Masayuki Yoshikawa: Absolute Stereostructures of Three New Sesquiterpenes from the Fruit of Alpinia oxyphylla with Inhibitory Effects on Nitric Oxide Production and Degranulation in RBL-2H3 Cells.J. Nat. Prod., 65, 1468-1474 (2002).
Hisashi Matsuda, Toshio Morikawa, Masayuki Yoshikawa: Antidiabetogenic Constituents from Several Natural Medicines.Pure Appl. Chem., 74, 1301-1308 (2002).
Hisashi Matsuda, Toshio Morikawa, Kazuho Ueda, Hiromi Managi, Masayuki Yoshikawa: Structural Requirements of Flavonoids for Inhibition of Antigen-Induced Degranulation, TNF-a and IL-4 Production from RBL-2H3 Cells.Bioorg. Med. Chem., 10, 3123-3128 (2002).
Masayuki Yoshikawa, Toshiyuki Murakami, Tomoko Ishiwada, Toshio Morikawa, Masatomo Kagawa, Yoshihiko Higashi, Hisashi Matsuda: New Flavonol Oligoglycosides and Polyacylated Sucrose with Inhibitory Effects on Aldose Reductase and Platelet Aggregation from the Flowers of Prunus mume.J. Nat. Prod., 65, 1151-1155 (2002).
Toshio Morikawa, Hisashi Matsuda, Yasuko Sakamoto, Kazuho Ueda, Masayuki Yoshikawa: New Farnesane-Type sesquiterpenes, Hedychiols A and B 8,9-Diacetate, and Inhibitors of Degranulation in RBL-2H3 Cells from the Rhizome of Hedychium coronarium.Chem. Pharm. Bull., 50, 1045-1049 (2002).
Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Shoichi Harima, Masayuki Yoshikawa: Medicinal Flowers. VI. Absolute Stereostructures of Two New Flavanone Glycosides and a Phenylbutanoid Glycoside from the Flowers of Chrysanthemum indicum L.: Their Inhibitory Activities for Rat Lens Aldose Reductase. Chem. Pharm. Bull ., 50, 972-975 (2002).
Hisashi Matsuda, Toshio Morikawa, Yasuko Sakamoto, Iwao Toguchida, Masayuki Yoshikawa: Labdane-type Diterpenes with Inhibitory Effects on Increase in Vascular Permeability and Nitric Oxide Production from Hedychium coronarium. Bioorg. Med. Chem ., 10, 2527-2534 (2002).
Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Masayuki Yoshikawa: Structural Requirements of Flavonoids and Related Compounds for Aldose Reductase Inhibitory Activity.Chem. Pharm. Bull., 50, 788-795 (2002).
Toshio Morikawa, Hisashi Matsuda, Kiyofumi Ninomiya, Masayuki Yoshikawa: Medicinal Foodstuffs. XXIX. Potent Protective Effects of Sesquiterpenes and Curcumin from Zedoariae Rhizoma on Liver Injury Induced by D-Galactosamine/Lipopolysaccharide or Tumor Necrosis Factor-alpha.Biol. Pharm. Bull., 25, 627-631 (2002).
Masayuki Yoshikawa, Toshio Morikawa, Hisashi Matsuda, Genzoh Tanabe, Osamu Muraoka: Absolute Stereostructure of Potent alpha-Glucosidase Inhibitor, Salacinol, with Unique Thiosugar Sulfonium Sulfate Inner Salt Structure from Salacia reticulata.Bioorg. Med. Chem., 10, 1547-1554 (2002).
Hisashi Matsuda, Yutana Pongpiriyadacha, Toshio Morikawa, Yousuke Kashima, Kyoko Nakano, Masayuki Yoshikawa: Protective Effects of Polygodial and Related Compounds on Ethanol-Induced Gastric Mucosal Lesions in Rats: Structural Requirements and Mode of Action.Bioorg. Med. Chem. Lett., 12, 477-482 (2002).
Hisashi Matsuda, Toshio Morikawa, Jing Tao, Kazuho Ueda, Masayuki Yoshikawa: Bioactive Constituents of Chinese Natural Medicines. VII. Inhibitors of Degranulation in RBL-2H3 Cells and Absolute Stereostructures of Three New Diarylheptanoid Glycosides from the Bark of Myrica rubra.Chem. Pharm. Bull., 50, 208-215 (2002).
Hisashi Matsuda, Toshio Morikawa, Yasuko Sakamoto, Iwao Toguchida, Masayuki Yoshikawa: Antiinflammatory Principles and Three New Labdane-type Diterpenes, Hedychilactones A, B, and C, from the Rhizome of Hedychium coronarium KOENG.Heterocycles, 56, 45-50 (2002).
2001
Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Kiyofumi Ninomiya, Masayuki Yoshikawa: Medicinal Foodstuffs. XXVIII. Inhibitors of Nitric Oxide Production and New Sesquiterpenes, Zedoarofuran, 4-Epicurcumenol, Neocurcumenol, Gajutsulactones A and B, and Zedoarolides A and B, from Zedoariae Rhizoma. Chem. Pharm. Bull ., 49, 1558-1556 (2001).
Masayuki Yoshikawa, Toshio Morikawa, kenichi Yashiro, Toshiyuki Murakami, Hisashi Matsuda: Bioactive Saponins and Glycosides. XIX. Notoginseng (3): Immunological Adjuvant Activity of Notoginsenosides and Related Saponins: Structures of Notoginsenosides-L, -M, and -N from the Roots of Panax notoginseng (BURK.) F. H. CHEN..Chem. Pharm. Bull., 49, 1452-1456 (2001).
Hisashi Matsuda, Toshio Morikawa, Kiyofumi Ninomiya, Masayuki Yoshikawa: Absolute Stereostructure of Carabrane-Type Sesquiterpene and Vasorelaxant Active Sesquiterpenes from Zedoariae Rhizoma.Tetrahedron, 57, 8443-8453 (2001).
Hisashi Matsuda, Toshio Morikawa, Hiroki Ueda, Masayuki Yoshikawa: Medicinal Foodstuffs. XXVII. Saponin Constituents of Gotu Kola (2): Structures of New Ursane-ane Oleanane-Type Triterpene Oligoglycosides, Centellasaponins B, C, and D, from Centella asiatica Cultivated in Sri Lanka.Chem. Pharm. Bull., 49, 1368-1371 (2001).
Masayuki Yoshikawa, Toshio Morikawa, Emi Fujiwara, Teruki Ohgushi, Yasunobu Asao, Hisashi Matsuda: New Noroleanane-Type Triterpene Saponins with Gastroprotective Effect and Platelet Aggregation Activity from the Flowers of Camellia japonica: Reviced Structures of Camellenodiol and Camelledionol.Heterocycles, 55, 1653-1657 (2001).
Osamu Muraoka, Genzoh Tanabe, Manabu Fujimoto, Michinori Kubo, Toshie Minematsu, Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Masayuki Yoshikawa: Absolute Stereostructures of Novel Norcadinane- and Trinoreudesmane-Type Sesquiterpenes with Nitric Oxide Production Inhibitory Activity from Alpinia oxyphylla.Bioorg. Med. Chem. Lett., 11, 2217-2220 (2001).
Hisashi Matsuda, Toshio Morikawa, Hiroki Ueda, Masayuki Yoshikawa: Medicinal Foodstuffs. XXVI. Inhibitors of Aldose Reductase and New Triterpene and Its Oligoglycoside, Centellasapogenol A and Centellasaponin A, from Centella asiatica (Gotu Kola).Heterocycles, 55, 1499-1504 (2001).
Hisashi Matsuda, Hiroshi Shimoda, Toshio Morikawa, Masayuki Yoshikawa: Phtoestrogens from the Roots of Polygonum cuspidatum (Polygonaceae): Structural Requirement of Hydroxyanthraquinones for Estrogenic Activity.Bioorg.Med. Chem. Lett., 11, 1839-1842 (2001).
Tadashi Kageura, Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, ShoichiHarima, Mamiko Oda, Masayuki Yoshikawa: Inhibitors from Rhubarb on Lipopolysaccharide?Induced Nitric Oxide Production in Macrophages: Structural Requirements of Stilbenes for the Activity,Bioorg. Med. Chem., 9, 1887-1893 (2001).
Hisashi Matsuda, Tadashi Kageura, Mamiko Oda, Toshio Morikawa, Yasuko Sakamoto, Masayuki Yoshikawa: Effects of Constituents from the Bark of Magnolia obovata on Nitric Oxide Production in Lipopolysaccharide-Activated Macrophages. Chem. Pharm. Bull ., 49, 716-720 (2001).
Hisashi Matsuda, Toshio Morikawa, Kiyofumi Ninomiya, Masayuki Yoshikawa: Hepatoprotective Constituents from Zedoariae Rhizoma: Absolute Stereostructures of Three New Carabrane-Type Sesquiterpenes, Curcumenolactones A, B, and C. Bioorg. Med. Chem ., 9, 909-916 (2001).
Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Kiyofumi Ninomiya, Masayuki Yoshikawa: Inhibitors of Nitric Oxide Production and New Sesquiterpenes, 4-Epicurcumenol, Neocurcumenol, Gajutsulactones A and B, and Zedoarolides A and B from Zedoariae Rhizoma.Heterocycles, 55, 841-846 (2001).
Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Ji-Young Park, Shoichi Harima, Masayuki Yoshikawa: Antioxidant Constituents from Rhubarb: Structural Requirements of Stilbenes for the Activity and Structures of Two Anthraquinone Giucosides,Bioorg. Med. Chem., 9, 41-50 (2001).
2000
Hisashi Matsuda, Tadashi Kageura, Yasunao Inoue, Toshio Morikawa, Masayuki Yoshikawa: Absolute Stereostructures and Syntheses of Saussureamines A, B, C, D, and E, Amino Acid?Sesquiterpene Conjugates with Gastroprotective Effect, from the Roots of Saussurea lappa,Tetrahedron, 56, 7763-7777 (2000).
Masayuki Yoshikawa, Hiroshi Shimoda, Toshiaki Uemura, Toshio Morikawa, Yuzo Kawahara, Hisashi Matsuda: Alcohol Absorption Inhibitors from Bay Leaf (Laurus nobilis): Structure-Requirements of Sesquiterpenes for the Activity,Bioorg. Med. Chem ., 8, 2071-2077 (2000).
Hisashi Matsuda, Tadashi Kagerura, Iwao Toguchida, Hiroki Ueda, Toshio Morikawa, Masayuki Yoshikawa. Inhibitory Effects of Sesquiterpenes from Bay Leaf on Nitric Oxide Production in Lipopolysaccharide-Activated Macrophages: Structure Requirement and Role of Heat Shock Protein Induction. Life Sci ., 66, 2151-2157 (2000).
Masayuki Yoshikawa, Toshio Morikawa, Iwao Toguchida, Shoichi Harima, Hisashi Matsuda: Medicinal Flowers. II. Inoacetate, E, F, and F Monoacetate from the Flowers of Chrysanthemum indicum L.,Chem. Pharm. Bull., 48, 651-656 (2000).
Hisashi Matsuda, Tadashi Kageura, Toshio Morikawa, Iwao Toguchida, Shoichi Harima, Masayuki Yoshikawa: Effect of Stilbene Constituents from Rhubarb on Nitric Oxide Production in Lipopolysaccharide-Activated Macrophages,Bioorg. Med. Chem. Lett., 10, 323-327 (2000).
