食品薬学研究室

〒577-8502 大阪府東大阪市小若江3-4-1
06-4307-4306
2025.10.03 更新

研究業績（論文）


2019

  • Toshio Morikawa, Akifumi Nagatomo, Takahiro Oka, Yoshinobu Miki, Norihisa Taira, Megumi Shibano-Kitahara, Osamu Muraoka, Kiyofumi Ninomiya. Glucose tolerance-improving activity of helichrysoside in mice and its structural requiremtns for promoting glucose and lipid metabolism.Int. J. Mol. Sci., 20, 6322 (2019).
  • Toshio Morikawa, Haihui Xie, Yingni Pan, Kiyofumi Ninomiya, Dan Yuan, Xiaoguang Jia, Masayuki Yoshikawa, Seikou Nakamura, Hisashi Matsuda, Osamu Muraoka, A review of biologically active natural products from a desert plant Cistanche tubulosa. Chem. Pharm. Bull., 67, 675-689 (2019). Review
  • Toshio Morikawa, Current Topics "Recent Research in Bioactive Natural Products from Traditional Medicinal Plants”. Chem. Pharm. Bull., 67, 632-633 (2019). Foreword. Cover Page
  • Toshio Morikawa, Shuhei Okugawa, Yoshiaki Manse, Osamu Muraoka, Masayuki Yoshikawa, Kiyofumi Ninomiya, Quantitative Determination of PrincipalAporphine and Benzylisoquinoline Alkaloids Due to Blooming State in Lotus Flower (Flower Buds of Nelumbo nucifera) and Their Hyaluronidase Inhibitory Activity. Nat. Prod. Commun., June 2019, 1-7 (2019).
  • Masakazu Kobayashi, Junji Akaki, Yasuyo Yamaguchi, Hiroo Yamasaki, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Masayuki Yoshikawa, Osamu Muraoka, Toshio Morikawa. Salacia chinensis stem extract and its thiosugar sulfonium constituent, neokotalanol, improves HbA1c levels in ob/ob mice. J. Nat. Med., 73, 584-588 (2019).

2018

  • 森川敏生，赤木淳二，Pongpiriyadacha Yutana，吉川雅之，二宮清文，村岡　修．サラシア属植物に含有されるポリフェノール成分のLCMS 定量分析． 日食化誌，25, 130-138 (2018).
  • Toshio Morikawa, Akifumi Nagatomo, Kayako Kitazawa, Osamu Muraoka, Takashi Kikuchi, Takeshi Yamada, Reiko Tanaka, Kiyofumi Ninomiya. Collagen synthesis-promoting effects of andiroba oil and its limonoid constituents in normal human dermal fibroblasts. J. Oleo Sci ., 67, 1271-1277 (2018).
  • Genzoh Tanabe, Sanami Teramae, Yousuke Kunikata, Shinsuke Marumoto, Shuhei Okugawa, Fumihiro Ishikawa, Wejia Xie, Toshio Morikawa, Osamu Muraoka. Synthesis of salacinol-d4 as an internal standard for mass-spectrometric quantitation of salacinol, a potent alpha-glucosidase inhibitor found in a traditional Ayurvedic medicine "Salacia". Heterocycles ., 97, 314-332 (2018).
  • Genzoh Tanabe, Yoshiaki Manse, Teppei Ogawa, Naoki Sonoda, Shinsuke Marumoto, Fumihiro Ishikawa, Kiyofumi Ninomiya, Saowanee Chaipech, Yutana Pongpiriyadacha, Osamu Muraoka, Toshio Morikawa. Total synthesis of gamma-alkylidenebutenolides, potent melanogenesis inhibitors from Thai medicinal plant Melodorum fruticosum. J. Org. Chem., 83, 8250-8264 (2018).
  • Norihisa Taira, Yushi Katsuyama, Masato Yoshioka, Osamu Muraoka, Toshio Morikawa. Structural requirements of alkylglyceryl-L-ascorbic acid derivatives for melanogenesis inhibitory activity. Int. J. Mol. Sci ., 19, 1144 (2018).
  • Toshio Morikawa, Yoshiaki Manse, Mika Koda, Saowanee Chaipech, Yutana Pongpiriyadacha, Osamu Muraoka, Kiyofumi Ninomiya. Two new aromatic glycosides, elengiosides A and B, from the flowers of Mimusops elengi., J. Nat. Med ., 72, 542-550 (2018).
  • Toshio Morikawa, Ikuko Hachiman, Kiyofumi Ninomiya, Hiroki Hata, Kaoru Sugawara, Osamu Muraoka, Hisashi Matsuda. Degranulation inhibitors from the arils of Myristica fragrans in antigen-stimulated rat basophilic leukemia cells. J. Nat. Med., 72, 464-473 (2018).
  • Toshio Morikawa, Katsuya Imura, Yoshinori Akagi, Osamu Muraoka, Kiyofumi Ninomiya. Ellagic acid glycosides with hepatoprotective activity from traditional Tibetan medicine Potentilla anserina. J. Nat. Med., 72, 317-325 (2018).
  • Fumihiro Ishikawa, Kazumi Jinno, Eri Kinouchi, Kiyofumi Ninomiya, Shinsuke Marumoto, Weijia Xie, Osamu Muraoka, Toshio Morikawa, Genzoh Tanabe. Diastereoselective synthesis of salacinol-type ?-glucosidase inhibitors.J. Org. Chem., 83, 185-193 (2018).

2017

  • Yoshiaki Manse, Kiyofumi Ninomiya, Akane Okazaki, Eriko Okada-Nishida, Takahiro Imagawa, Mami Imamura-Mizushima, Yuki Yamano, Kinji Kaname, Sho Nakamura, Toshio Morikawa: Melanogenesis inhibitory activity of diterpenoid and triterpenoid constituents from the aerial part of Isodon trichocarpus.Nat. Prod. Commun., 12, 1185-1188 (2017).
  • Toshio Morikawa, Hisashi Matsuda, Masayuki Yoshikawa: A review of anti-inflammatory terpenoids from the incense gum resins frankincense and myrrh.J.Oleo. Sci., 66, 805-814 (2017).Review
  • Genzoh Tanabe, Nozomi Tsutsui, Kanae Shibatani, Shinsuke Marumoto, Fumihiro Ishikawa, Kiyofumi Ninomiya, Osamu Muraoka, Toshio Morikawa: Total synthesis of the aromatase inhibitors, mammeasins C and D, from Thai medicinal plant Mammea siamensis.Tetrahedron, 73, 4481-4486 (2017).
  • 森川敏生：薬学領域からの機能性食品素材開発-サラシアの抗糖尿病効果-．大阪府薬雑誌，68，51-58 (2017).
  • Kiyofumi Ninomiya, Saowanee Chaipech, YusukeKunikata, Ryohei Yagi, Yutana Pongpiriyadacha, Osamu Muraoka, Toshio Morikawa: Quantitative determination of stilbenoids and dihydroisocoumarins in Shorea roxburghii and evaluation of their hepatoprotective activity.Int. J. Mol. Sci., 18, 451 (2017).
  • 矢作忠弘，石内勘一郎，渥美聡孝，三宅克典，森永 紀，伏見裕利，大山雅義，森川敏生，田中 謙，有田正規，牧野利明：歴代教科書・解説書に見られる生薬の効能に関する記載のデータベース化（２）．生薬学雑誌，71, 20-36 (2017).
  • 矢作忠弘，石内勘一郎，渥美聡孝，三宅克典，森永 紀，伏見裕利，大山雅義，森川敏生，田中 謙，有田正規，牧野利明：歴代教科書・解説書に見られる生薬の効能に関する記載のデータベース化（１）．生薬学雑誌，71, 1-19 (2017).

2016

  • Toshio Morikawa, Niichiro Kitagawa, Chiaki Motai, Kiyofumi Ninomiya, Shuhei Okugawa, Ayaka Nishida, Masayuki Yoshikawa, Osamu Muraoka: The antiproliferative effect of chakasaponins I and II, floratheasaponin A, and epigallocatechin 3-O-gallate isolated from Camellia sinensis on human digestive tract carcinoma cell lines.Int. J.Mol. Sci., 17, 1979 (2016).
  • Yoshiaki Manse, Kiyofumi Ninomiya, Ryosuke Nishi, Iyori Kamei, Yushi Katsuyama, Takahiro Imagawa, Saowanee Chaipech, Osamu Muraoka, Toshio Morikawa: Melanogenesis inhibitory activity of a 7-O-9'-linked neolignan from Alpinia galanga fruit. Bioorg.Med. Chem., 24, 6215-6224 (2016).
  • Hiroyuki Moriyama, Mariko Moriyama, Kiyofumi Ninomiya, Toshio Morikawa, Takao Hayakawa: Inhibitory effects of oligostilbenoids from the bark of Shorea roxburghii on malignant melanoma cell growth: inplications for novel topical anticancer candidate.Biol. Pharm. Bull., 39, 1675-1682 (2016).
  • Toshio Morikawa, Ikuko Hachiman, Kazuhiko Matsuo, Eriko Nishida, Kiyofumi Ninomiya, Takao Hayakawa, Osamu Yoshie, Osamu Muraoka, Takashi Nakayama: Neolignans from the arils of Myristica fragrans as potent antagonists of CC chemokine receptor 3. J.Nat. Prod., 79, 2005-2013 (2016).
  • Hisashi Matsuda, Seikou Nakamura, Toshio Morikawa, Osamu Muraoka, Masayuki Yoshikawa: New biofunctional effects of the flower buds of Camellia sinensis and its bioactive acylated oleanane-type triterpene oligoglycoside.J. Nat. Med., 70, 689-701 (2016).
  • Genzoh Tanabe, Weijia Xie, Gorre Balakishan, Mumen F. A. Amer, Nozomi Tsutsui, Haruka Takemura, Shinya Nakamura, Junji Akaki, Kiyofumi Ninomiya, Toshio Morikawa, Isao Nakanishi, Osamu Muraoka: Hydrophobic substituents increase the potency of salacinol, a potent alpha-glucosidase inhibitor from Ayurvedic traditional medicine 'Salacia'.Bioorg. Med. Chem., 24, 3705-3715 (2016).
  • Niichiro Kitagawa, Kiyofumi Ninomiya, Shuhei Okugawa, Chiaki Motai, Yusuke Nakanishi, Masayuki Yoshikawa, Osamu Muraoka, Toshio Morikawa: Quantitative determination of principal alkaloid and flavonoid constituents in Wintersweet, the flower buds of Chimonanthus praecox.Nat. Prod. Commun., 11, 953-956 (2016).
  • Toshio Morikawa, Niichiro Kitagawa, Genzoh Tanabe, Kiyofumi Ninomiya, Shuhei Okugawa, Chiaki Motai, Iyori Kamei, Masayuki Yoshikawa, I-Jung Lee, Osamu Muraoka: Quantitative determination of alkaloids in Lotus Flower (flower buds of Nelumbo nucifera) and their melanogenesis inhibitory activity.Molecules, 21, 930 (2016).
  • Kiyofumi Ninomiya, Chiaki Motai, Eriko Nishida, Niichiro Kitagawa, Kazuya Yoshihara, Takao Hayakawa, Osamu Muraoka, Xuezheng Li, Seikou Nakamura, Masayuki Yoshikawa, Hisashi Matsuda, Toshio Morikawa: Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.J. Nat. Med., 70, 435-451 (2016).
  • Kiyofumi Ninomiya, Kanae Shibatani, Mayumi Sueyoshi, Saowanee Chaipech, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka, Toshio Morikawa: Aromatase inhibitory activity of geranylated coumarins, mammeasins C and D, isolated from the flowers of Mammea siamensis.Chem. Pharm. Bull., 64, 880-885 (2016).
  • Kazuhiko Matsuo, Keiichi Koizumi, Mitsugu Fujita, Toshio Morikawa, Michiko Jo, Naotoshi Shibahara, Ikuo Saiki, Osamu Yoshie, Takashi Nakayama: Efficient use of a crude drug/herb library reveals Ephedra Herb as a specific antagonist for TH2-specific chemokine receptors CCR3, CCR4, and CCR8. Front.Cell Develop. Biol., 4, 54 (2016).
  • Kiyofumi Ninomiya, Seiya Miyazawa, Kaiten Ozeki, Natsuko Matsuo, Osamu Muraoka, Takashi Kikuchi, Takeshi Yamada, Reiko Tanaka, Toshio Morikawa: Hepatoprotective limonoids from Andiroba (Carapa guianensis).Int. J. Mol. Sci., 17, 591 (2016).
  • 小林正和，赤木淳二，山田康代，山崎寛生，森川敏生，二宮清文，吉川雅之，村岡 修：サラシアエキス末配合食品の長期摂取時および過剰摂取時の安全性の検討．Jpn. Pharmacol. Ther.，44, 399-408 (2016).
  • Kiyofumi Ninomiya, Taku Matsumoto, Saowanee Chaipech, Sohachiro Miyake, Yushi Katsuyama, Akihiro Tsuboyama, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka, Toshio Morikawa: Simultaneous quantitative analysis of 12 methoxyflavones with melanogenesis inhibitory activity from the rhizomes of Kaempferia parviflora.J.Nat. Med., 70, 179-189 (2016).
  • Toshio Morikawa, Kiyofumi Ninomiya, Hiroyuki Kuramoto, Iyori Kamei, Masayuki Yoshikawa, Osamu Muraoka: Phenylethanoid and phenylpropanoid glycosides with melanogenesis inhibitory activity from the flowers of Narcissus tazetta var. chinensis.J. Nat. Med., 70, 89-101 (2016).

2015

  • 中村恭子，赤木淳二，石伏史明，谷 恭輔，森川敏生，Pongpiriyadacha Yutana，村岡 修，早川堯夫，角谷晃司：rDNA ITS 領域の塩基配列による Salacia chinsnsis の鑑別．生薬学雑誌，69, 53-58 (2015).
  • Toshio Morikawa, Kiyofumi Ninomiya, Junji Akaki, Namiko Kakihara, Hiroyuki Kuramoto, Yurie Matsumoto, Takao Hayakawa, Osamu Muraoka, Li-Bo Wang, Li-JUn Wu, Seikou Nakamura, Masayuki Yoshikawa, Hisashi Matsuda: Dipeptidyl peptidase-IV inhibitory activity of dimeric dihydrochalcone glycosides from flowers of Helichrysum arenarium.J. Nat. Med., 69, 494-506 (2015).J. Nat. Med. Award 2015
  • Gnezoh Tanabe, Youta Sugano, Miki Shirato, Naoki Sonoda, Nozomi Tsutsui, Toshio Morikawa, Kiyofumi Ninomiya, Masayuki Yoshikawa, Osamu Muraoka: Total synthesis of 4,5-dihydroguadiscine: a potent melanogenesis inhibitor from the Brazillian medicinal herb, Hornschuchia obliqua.J. Nat. Prod., 78, 1536-1542 (2015).
  • Takanoibu Inoue, Yuuki Matsui, Takashi Kikuchi, Takeshi Yamada, Yasuko In, Osamu Muraoka, Chie Sakai, Kiyofumi Ninomiya, Toshio Morikawa, Reiko Tanaka: Carapanolides M-S from seeds of andiroba (Carapa guianensis, Meliaceae) and triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells.Tetrahedron, 71, 2753-2760 (2015).
  • Toshio Morikawa, Junji Akaki, Kiyofumi Ninomiya, Eri Kinouchi, Genzoh Tanabe, Yutana Pongpiriyadacha, Masayuki Yoshikawa, Osamu Muraoka: Salacinol and related analogs: new leads for type 2 diabetes therapeutic candidates from the Thai traditional natural medicine Salacia chinensis.Nutrients, 7, 14801-1493 (2015).
  • Asami Sakamoto, Yuji Tanaka, Takeshi Yamada, Takashi Kikuchi, Osamu Muraoka, Kiyofumi Ninomiya, Toshio Morikawa,* Reiko Tanaka: Andirolides W-Y from the flower oil of andiroba (Carapa guianensis, Meliaceae).Fitoterapia, 100, 81-87 (2015).

2014

  • Toshio Morikawa, Junji Akaki, Kiyofumi Ninomiya, Eri Kinouchi, Genzoh Tanabe, Masayuki Yoshikawa, Salacinol and related analogs, new leads for type 2 diabetes therapeutic candidates from Thai traditional natural medicine Salacia chinensis.Nutrients, 6, 4147 (2014). Mini-Review
  • Junji Akaki, Toshio Morikawa, Sohachiro Miyake, Kiyofumi Ninomiya, Mayumi Okada, Genzoh Tanabe, Yutana Pongpiriyadacha, Masayuki Yoshikawa, Osamu Muraoka: Evaluationof Salacia species as anti-diabetic natural resources based on quantitative analysis of eight sulphonium constituents: a new class of alpha-glucosidase inhibitors.Phytochem. Anal., 25, 544-550 (2014).
  • Toshio Morikawa, Kiyofumi Ninomiya, Mio Imamura, Junji Akaki, Shota Fujikura, Yingni Pan, Dan Yuan, Masayuki Yoshikawa, Xiaoguang Jia, Zheng Li, Osamu Muraoka: Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice.J. Nat. Med., 68, 561-566 (2014).
  • Toshio Morikawa, Yusuke Nakanishi, Kiyofumi Ninomiya, Hisashi Matsuda, Souichi Nakashima, Hisako Miki, Yu Miyashita, Masayuki Yoshikawa, Takao Hayakawa, Osamu Muraoka: Dimeric pyrrolidinoindoline-type alkaloids with melanogenesis inhibitory activity in flower buds of Chimonanthus praecox.J. Nat. Med., 68, 539-549 (2014).
  • Toshio Morikawa, Kiyofumi Ninomiya,KatsuyaImura, Takahira Yamaguchi, Yoshinori Akagi, Masayuki Yoshikawa, Takao Hayakawa, Osamu Muraoka: Hepatoprotective triterpenes from traditional Tibetan medicine Potentilla anserina.Phytochemistry, 102, 169-181 (2014).

2013

  • Toshio Morikawa, I-Jung Lee, Shuhei Okugawa, Sohachiro Miyake, Yoshinobu Miki, Kiyofumi Ninomiya, Niichiro Kitagawa, Masayuki Yoshikawa, Osamu Muraoka: Quantitative analysis of catechin, flavonoid, and saponin constituents in "Tea Flower", the flower buds of Camellia sinensis, from different regions in Taiwan.Nat. Prod.Commun., 8, 1553-1557 (2013).
  • Weijia Xie, Genzoh Tanabe, Jinyi Xu, Toshio Morikawa, Masayuki Yoshikawa, Osamu Muraoka: Research progress of synthesis and structure-activity relationship studies on sulfonium-type alpha-glucosidase inhibitors isolated from Salacia genus plants.Mini-Rev. Org. Chem., 10, 141-150 (2013).
  • Toshio Morikawa, Kiyofumi Ninomiya, Sohachiro Miyake, Yoshinobu Miki, Masaki Okamoto, Masayuki Yoshikawa, Osamu Muraoka: Flavonol glycosides with lipid accumulation inhibitory activity and simultaneous quantitative analysis of 15 polyphenols and caffeine in the flower buds of Camellia sinensis from different regions by LCMS.Food Chem., 140, 353-360 (2013).
  • Toshio Morikawa, Kiyofumi Ninomiya, FengmingXu, Naomichi Okumura, Hisashi Matsuda, Osamu Muraoka, Takao Hayakawa, Masayuki Yoshikawa: Acylated dolabellane-type diterpenes from Nigella sativa seeds with triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells.Phytochemistry Lett., 6, 198-204 (2013).

2012

  • Toshio Morikawa, Mayumi Sueyoshi, SAowanee Chaipech, Hisashi MAtsuda, Yukiko Nomura, Mikuko Yabe, Tomoko Matsumoto, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yutana Pongipiriyadacha, Takao Hayakawa, Osamu Muraoka: Suppressive effects of coumarins from Mammea siamensis on inducible nitric oxide synthase expression in RAW264.7 cell.Bioorg. Med. Chem., 20, 4968-4977 (2012).
  • Genzoh Tanabe, Shinya Nakamura, Nozomi Tsutsui, Gorre Balakishan, Weijia Xie, Satoshi Tsuchiya, Junji Akaki, Toshio Morikawa, Kiyofumi Ninomiya, Masayuki Yoshikawa, Isao Nakanishi, Osamu Muraoka: In silico desing, synthesis and evaluation of 3'-O-benzylated analogs of salacinol, a potent alpha-glucosidase inhibitor isolated from an Ayurvedic traditional medicine "Salacia".Chem. Comm., 48, 8646-8648 (2012).
  • Toshio Morikawa, Sohachiro Miyake, Yoshinobu Miki, Kiyofumi Ninomiya, Masayuki Yoshikawa, Osamu Muraoka: Quantitative analysis of acylated oleanane-type triterpene saponins, chakasaponins I-III and floratheasaponins A-F, in the flower buds of Camellia sinensis from different regional origins.J. Nat. Med., 66, 608-613 (2012).
  • Toshio Morikawa, Saowanee Chaipech, Hisashi Matsuda, Makoto Hamao, Yohei Umeda, Hiroki Sato, Haruka Tamura, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka: Anti-hyperlipidemic constituents from the bark of Shorea roxburghii.J. Nat. Med., 66, 516-524 (2012).
  • Saowanee Chaipech, Toshio Morikawa, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yutana Pongiriyadacha, Takao Hayakawa, Osamu Muraoka: New flav-3-en-3-ol glycosides, kaempferiaosides C and D, and acetophenone glycosides, kaempferiaosides E and F, from the rhizomes of Kaempferia parviflora.J. Nat. Med., 66, 486-492 (2012).
  • Toshio Morikawa, Kiyofumi Ninomiya, Yi Zhang, Tomomi Yamada, Seikou Nakamura, Hisashi Matsuda, Osamu Muraoka, Takao Hayakawa, Masayuki Yoshikawa: Flavonol glycosides with lipid accumulation inhibitory activity fromSedum sarmentosum.Phytochemistry Lett., 5, 53-58 (2012).
  • Toshio Morikawa, Saowanee Chaipech, Hisashi Matsuda, Makoto Hamao, Yohei Umeda, Hiroki Sato, Haruka Tamura, Haruka Kon'i, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka: Antidiabetogenic oligstilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii.Bioorg. Med. Chem., 20, 832-840 (2012).
  • Saowanee Chaipech, Toshio Morikawa, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka: Structures of two new phenolic glycosides, kaempferiaosides AandB, and hepatoprotective constituents from the rhizomes of Kaempferia parviflora.Chem. Pharm. Bull., 60, 62-69 (2012).
  • Toshio Morikawa, Katsuya Imura,SohachiroMiyake, Kiyofumi Ninomiya, Hisashi Matsuda, Chihiro Yamashita, Osamu Muraoka, Takao Hayakawa, Masayuki Yoshikawa: Promoting the effect of chemical constituents from the flowers of Poacynum hendersonii on adipogenesis in 3T3-L1 cells.J. Nat. Med., 66, 39-48 (2012).

2011

  • Toshio Morikawa, Xuezheng Li, Eriko Nishida, Seikou Nakamura, Kiyofumi Ninomiya, Hisashi Matsuda, Makoto Hamao, Osamu Muraoka, Takao Hayakawa, Masayuki Yoshikawa: Medicinal flowers. XXXII. structures of oleanane-type triterpene saponins, perennisosides VIII, IX, X, XI, and XII, from the flowers of Bellis perennis.Chem.Pharm. Bull., 59, 889-895 (2011).
  • Weijia Xie, Genzoh Tanabe, Junji Akaki, Toshio Morikawa, Kiyofumi Ninomiya, Toshie Minematsu, Masayuki Yoshikawa, Xiaoming Wu, Osamu Muraoka: Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent alpha-glucosidase inhibitors.Bioorg. Med. Chem., 19, 2015-2022 (2011).
  • Osamu Muraoka, Toshio Morikawa, Sohachiro Miyake, Junji Akaki, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Masayuki Yoshikawa: Quantitative analysis of neosalacinol and neokotalanol, another two potent alpha-glucosidase inhibitors fromSalacia species, by LC-MS with ion pair chromatography. J. Nat. Med., 65, 142-148 (2011).
  • Toshio Morikawa, Hideo Oominami, Hisashi Matsuda, Masayuki Yoshikawa: New terpenoids, olibanumols D-G, from traditional Egyptian medicine olibanum, the gum-resin ofBoswallia carterii.J. Nat. Med., 65, 129-134 (2011).

2010

  • Toshio Morikawa, Hideo Oominami, Hisashi Matsuda, Masayuki Yoshikawa: Four new ursane-type triterpenes, olibanumols K, L, M, and N, from traditional Egyptian medicine olibanum, the gum-resin ofBoswellia carterii.Chem. Pharm. Bull., 58, 1541-1544 (2010).
  • Toshio Morikawa, Yingni Pan, Kiyofumi Ninomiya, Katsuya Imura, Dan Yuan, Masayuki Yoshikawa, Takao Hayakawa, Osamu Muraoka: Iridoid and acyclic monoterpene glycosides, kankanosides L, M, N, O, and P from Cistanche tubulosa.Chem. Pharm. Bull., 58, 1403-1407 (2010).
  • Toshio Morikawa, Fengming Xu, Hisashi Matsuda, Masayuki Yoshikawa: Structures of novel norstilbene dimer, longusone A, and stilbene dimers, longusols A, B, and C, with antiallergic and radical scavenging activities from Egyptial natural medicine Cyperus longus.Chem. Pharm. Bull., 58, 1379-1385 (2010).
  • Toshio Morikawa, Yuanyuan Xie, Kiyofumi Ninomiya, Masaki Okamoto, Osamu Muraoka, Dan Yuan, Masayuki Yoshikawa, Takao Hayakawa: Inhibitory effects of acylated sesquiterpene oligoglycosides from the pericarps of Sapindus rarak on tumor necrosis factor-alpha-induced cytotoxicity.Chem. Pharm. Bull., 58, 1276-1280 (2010).
  • 小林正和，赤木淳二，山下耕作，森川敏生，二宮清文，吉川雅之，村岡 修：サラシアエキス配合食品の食後血糖上昇抑制効果，薬理と治療，38, 545-550 (2010).
  • Shinya Nakamura, Kazunori Takahira, Genzoh Tanabe, Toshio Morikawa, Mika Sakano, Kiyofumi Ninomiya,Masayuki Yoshikawa, Osamu Muraoka, Iso Nakanishi: Docking and SAR studies of salacinol derivatives as alpha-glucosidase inhibitors.Bioorg. Med. Chem. Lett., 20, 4420-4423 (2010).
  • 森川敏生：TNF-alpha感受性低減作用を指標とした香辛料由来生物活性成分の探索－タイ天然薬物Piper chabaの肝保護作用成分－，薬学雑誌，130, 785-791 (2010). Review
  • 森川敏生，村岡 修，吉川雅之：食品薬学：薬食同源の視点から薬用食品を科学する－デイジーフラワーの中性脂質上昇抑制作用サポニン成分－，薬学雑誌，130, 673-678 (2010). Review
  • Hisashi Matsuda, Souichi Nakashima, Osama Bashir Abdel-Halim, Toshio Morikawa, Masayuki Yoshikawa: Cucurbitane-type triterpenes with anti-proliferative effects on U937 from an Egyptian natural medicine, Bryonia cretica: styructures of new triterpene glycosides, bryoniaosides A and B. Chem.Pharm. Bull., 58, 747-751 (2010).
  • Osamu Muraoka, Weijia Xie, Satomi Osaki, Ayumi Kagawa, Genzoh Tanabe, Mumen F. A. Amer, Toshie Minematsu, Toshio Morikawa, Masayuki Yoshikawa: Characteristic alkaline catalyzed degradation of kotalanol, a potent alpha-glucosidase inhibitor isolated from Ayurvedic traditional medicine Salacia reticulata, leading to anhydroheptitols: another structural proof.Tetrahedron, 66, 3717-3722 (2010).
  • Osamu Muraoka, Toshio Morikawa, Sohachiro Miyake, Junji Akaki, Kiyofumi Ninomiya, Masayuki Yoshikawa: Quantitative determination of potent alpha-glucosidase inhibitors, salacinol and kotalanol, in Salacia species using liquid chromatography-mass spectrometry.J. Pharm. Biomed. Anal., 52, 770-773 (2010).
  • Toshio Morikawa, Xuezheng Li, Eriko Nishida, Seikou Nakamura, Kiyofumi Ninomiya, Hisashi Matsuda, Yoshimi Oda, Osamu Muraoka, Masayuki Yoshikawa: Medicinal flowers part 29 Acylated oleanane-type triterpene bisdesmosides: perennisaponins G, H, I, J, K, L, and M with pancreatic lipase inhibitory activity from the flowers of Bellis perennis.Helv. Chim. Acta, 93, 573-586 (2010).
  • Toshio Morikawa, Yingni Pan, Kiyofumi Ninomiya, Katsuya Imura, Hisashi Matsuda, Masayuki Yoshikawa, Dan Yuan, Osamu Muraoka: Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa.Bioorg. Med. Chem., 18, 1882-1890 (2010).


近畿大学アンチエイジングセンター 公式HP
近畿大学アンチエイジングセンター
民間薬・薬草研究会（工事中）
民間薬・薬草研究会